(function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':
new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],
j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src=
'https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);
})(window,document,'script','dataLayer','GTM-WZZLD89');
window.addEventListener('pushdatalayer', function(event) {
const section = event.detail?.siteSection;
const subsection = event.detail?.siteSubsection;
const pageUrl = event.detail?.pageUrl;
const pageTitle = event.detail?.pageTitle;
const promptSelection = event.detail?.promptSelection;
const formId = event.detail?.formId;
const dataLayerEvent = {
event: event.detail.eventName,
eventCallback: function () {
document.dispatchEvent(new CustomEvent('postdatalayerpush', {
bubbles: true,
composed: true,
detail: event.detail,
}));
},
};
if (section) {
dataLayerEvent['site_section'] = section;
}
if (subsection) {
dataLayerEvent['site_subsection'] = subsection;
}
if (pageUrl) {
dataLayerEvent['pageUrl'] = pageUrl;
}
if (pageTitle) {
dataLayerEvent['pageTitle'] = pageTitle;
}
if(promptSelection){
dataLayerEvent['promptSelection'] = promptSelection;
}
if(formId){
dataLayerEvent['form_ID'] = formId;
}
window.dataLayer = window.dataLayer || [];
window.dataLayer.push(dataLayerEvent);
});
document.addEventListener('checkcookie', () => {
var hasCookie = document.cookie.split(';')
.some((cookie) => cookie.trim().startsWith('CookieConsent='));
document.dispatchEvent(new CustomEvent('hascookie', { detail: hasCookie }));
});
Overview Lublin et al., 2014The most common CIS presentations and risk factors for Clinically Definite MS (Brownlee and Miller, 2014 ) include: Optic Neuritis Unilateral reduced visual acuity Orbital pain particularly with eye movement Reduced color vision Afferent pupillary defect Retrobulbar or mild disc swelling Brainstem Bilateral internuclear ophthalmoplegia Ataxia and gaze evoked nystagmus 6th nerve palsy Multi-focal symptoms Facial sensory loss Vertigo Ataxia Dysarthria Spinal Cord Incomplete transverse myelitis Positive Lhermitte’s sign Sphincter symptoms Asymmetric limb weakness Symptom progression between 4 hours and 21 days. Clinically isolated syndrome (CIS) is a term that describes a first clinical episode of a disease that shows characteristics of inflammatory demyelination that could be MS but has yet to fulfill criteria of dissemination in time. (Lublin et al., 2014 ) It usually occurs in young adults and affects optic nerves, the brainstem, or the spinal cord. Although patients usually recover from their presenting episode, CIS is often the first manifestation of MS. The most common CIS presentations and risk factors for Clinically Definite MS (Brownlee and Miller, 2014 ) include: Optic Neuritis Unilateral reduced visual acuity Orbital pain particularly with eye movement Reduced color vision Afferent pupillary defect Retrobulbar or mild disc swelling Brainstem Bilateral internuclear ophthalmoplegia Ataxia and gaze evoked nystagmus 6th nerve palsy Multi-focal symptoms Facial sensory loss Vertigo Ataxia Dysarthria Spinal Cord Incomplete transverse myelitis Positive Lhermitte’s sign Sphincter symptoms Asymmetric limb weakness Symptom progression between 4 hours and 21 days. Lublin et al., 2014The most common CIS presentations and risk factors for Clinically Definite MS (Brownlee and Miller, 2014 ) include: Optic Neuritis Unilateral reduced visual acuity Orbital pain particularly with eye movement Reduced color vision Afferent pupillary defect Retrobulbar or mild disc swelling Brainstem Bilateral internuclear ophthalmoplegia Ataxia and gaze evoked nystagmus 6th nerve palsy Multi-focal symptoms Facial sensory loss Vertigo Ataxia Dysarthria Spinal Cord Incomplete transverse myelitis Positive Lhermitte’s sign Sphincter symptoms Asymmetric limb weakness Symptom progression between 4 hours and 21 days. Clinically isolated syndrome (CIS) is a term that describes a first clinical episode of a disease that shows characteristics of inflammatory demyelination that could be MS but has yet to fulfill criteria of dissemination in time. (Lublin et al., 2014 ) It usually occurs in young adults and affects optic nerves, the brainstem, or the spinal cord. Although patients usually recover from their presenting episode, CIS is often the first manifestation of MS. The most common CIS presentations and risk factors for Clinically Definite MS (Brownlee and Miller, 2014 ) include: Optic Neuritis Unilateral reduced visual acuity Orbital pain particularly with eye movement Reduced color vision Afferent pupillary defect Retrobulbar or mild disc swelling Brainstem Bilateral internuclear ophthalmoplegia Ataxia and gaze evoked nystagmus 6th nerve palsy Multi-focal symptoms Facial sensory loss Vertigo Ataxia Dysarthria Spinal Cord Incomplete transverse myelitis Positive Lhermitte’s sign Sphincter symptoms Asymmetric limb weakness Symptom progression between 4 hours and 21 days.
Risk Factors Cinar et al., 2018> 2 T2 MRI lesions (Kuhle et al., 2015 ; Cinar et al., 2018 ) Oligoclonal bands present in CSF, not in serum (Kuhle et al., 2015 ) " c-nmssatomrichtext_nmssatomrichtext-host="">The important risk factors for the conversion to clinically definite MS (CDMS) are: Cinar et al., 2018> 2 T2 MRI lesions (Kuhle et al., 2015 ; Cinar et al., 2018 ) Oligoclonal bands present in CSF, not in serum (Kuhle et al., 2015 ) " c-nmssatomrichtext_nmssatomrichtext-host="">The important risk factors for the conversion to clinically definite MS (CDMS) are:
Treatment of CIS disease modifying treatments have an FDA indication to delay conversion of CIS to MS" c-nmssatomrichtext_nmssatomrichtext-host=""> disease modifying treatments have an FDA indication to delay conversion of CIS to MS" c-nmssatomrichtext_nmssatomrichtext-host="">
Clinically Isolated Syndrome