Restoring Function

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disease-modifying therapies can limit relapses and delay disease progression for many, they do not erase symptoms or restore abilities.To do this, researchers are focusing on:

An integrated approach to repairing myelin
Better understanding how wellness and lifestyle choices can improve symptoms

Read about the research teams funded by the National Multiple Sclerosis Society that are leading the way in finding ways to repair myelin and restore function." c-nmssatomrichtext_nmssatomrichtext-host="">

Restoring function means repairing the damage multiple sclerosis has done to the central nervous system. This would allow people to recover abilities lost due to MS. While disease-modifying therapies can limit relapses and delay disease progression for many, they do not erase symptoms or restore abilities.To do this, researchers are focusing on:

An integrated approach to repairing myelin
Better understanding how wellness and lifestyle choices can improve symptoms

Read about the research teams funded by the National Multiple Sclerosis Society that are leading the way in finding ways to repair myelin and restore function.

disease-modifying therapies can limit relapses and delay disease progression for many, they do not erase symptoms or restore abilities.To do this, researchers are focusing on:

An integrated approach to repairing myelin
Better understanding how wellness and lifestyle choices can improve symptoms

An integrated approach to repairing myelin
Better understanding how wellness and lifestyle choices can improve symptoms

Read about the research teams funded by the National Multiple Sclerosis Society that are leading the way in finding ways to repair myelin and restore function.

Repairing Myelin

RealTalkMS podcast featuring Dr. Zuchero to learn more (begin at 13:30).

Home-Based Trials

Myelin repair in people has largely been measured through nerves in the eyes, limiting the pool of research participants to those with vision problems. Home-based trials using tools that assess other aspects of a person’s function could speed up the testing of promising myelin repair strategies.Riley Bove, MD, MSc (University of California, San Francisco) and colleagues have found that a specific molecule promotes myelin repair in lab animals. They are now testing this molecule in a home-based trial of 50 women with MS. In this trial, they are using questionnaires, video conference interviews and other digital tools to measure the success of the experimental therapy." c-nmssatomrichtext_nmssatomrichtext-host="">

Myelin is formed by cells (oligodendrocytes) that wrap around nerve fibers (axons). In MS, some long-standing damaged areas of the brain and spinal cord fail to regenerate myelin. When oligodendrocytes are present in these lesions, they are blocked from being able to repair damage. This is what causes a loss of function.

Restarting Myelin Repair

J. Bradley Zuchero, PhD (Stanford University) is studying myelin wrapping as it occurs normally in lab dishes and in a mouse model. Specifically, his team is investigating the role of structural scaffolding, called the cytoskeleton, which is present inside oligodendrocytes. This work may unlock the key to restarting myelin repair. Listen to a RealTalkMS podcast featuring Dr. Zuchero to learn more (begin at 13:30).

Home-Based Trials

RealTalkMS podcast featuring Dr. Zuchero to learn more (begin at 13:30).

Home-Based Trials

Restarting Myelin Repair

Home-Based Trials

Restoring Function

Watch Dr. Fling and others discuss their research.

Depression and Restoring Function

Depression and other mood disorders are common in people with MS. Being depressed has been linked to increased disability, lower quality of life and more severe fatigue and pain symptoms. Identifying depression as early as possible can help restore function to people who live with MS.Toward this aim, Kathryn Fitzgerald, ScD (Johns Hopkins University) and team are looking for early signals of depression using novel methods. For example, the team is using activity monitors to measure 24-hour biological rhythms of people with MS and seeing if the readings relate to depression." c-nmssatomrichtext_nmssatomrichtext-host="">

People with MS often report significant differences in strength and function between their right and left legs. Differences in strength have been linked to poor walking ability, falls and a reduced quality of life.Brett Fling, PhD (Colorado State University) and his team are testing the potential of a split-belt treadmill, where the speed of each leg can be controlled independently. This is designed to reduce strength differences and improve mobility in people with MS. The team is also using wearable sensors to see whether improvements using the treadmill can be translated to the typical walking that people do at home. Watch Dr. Fling and others discuss their research.

Depression and Restoring Function

Watch Dr. Fling and others discuss their research.

Depression and Restoring Function

Explore Research Projects Supported by the Society

Stop MS

This pathway focuses on early detection and treatment, as well as precision medicine.

End MS

This pathway aims to end MS by preventing the disease before it occurs.

Pathways to Cures

The Society is bringing the world together to cure MS for every single person.

Research News About Restoring Function

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Research We Fund To Restore Lost Function

Repairing Myelin

Restoring Function

Explore Research Projects Supported by the Society

Research News About Restoring Function

Estudio financiado por la Sociedad Nacional de Esclerosis Múltiple señala posible estrategia nueva para reparar la mielina

Personas con esclerosis múltiple tienen el doble de probabilidad de tener algún tipo de dolor de cabeza, según un nuevo estudio limitado.

Investigadores se unen para identificar importante gen en la formación de mielina

Células madre restauran la mielina en ratones

Estudio financiado por la Sociedad Nacional de Esclerosis Múltiple vincula las mitocondrias, que producen energía, al daño celular con la enfermedad