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Investigators in Greece report that 96 people with MS were more than twice as likely to be diagnosed with any type of headache, and with migraine specifically, when compared with 96 people without MS. People with MS had higher levels of pain intensity and more frequent episodes of headache, compared with people without MS. Get strategies for preventing and treating headaches below. Background: Research shows that headache can appear as a symptom of MS. Most studies have been retrospective, a format that requires people to recall headache frequency and severity after the fact. A “prospective” study, which follows participants as the events are occurring, may produce more accurate findings.The Study: A team from National and Kapodistrian University of Athens tracked 96 people with MS and 96 controls without MS for two years. Participants filled out structured headache diaries that captured many aspects of headaches, including episode frequency and duration; pain location, quality and intensity; and monthly use of pain relievers.Results: Using powerful statistical methods to analyze the diaries, the team showed that people with MS were more than twice as likely to be diagnosed with any type of headache. Those with MS were more than twice as likely to be diagnosed with migraine headaches specifically.People with MS reported longer attack duration, higher pain intensity and increased frequency of episodes, compared with people without MS. The group with MS used pain relievers more frequently than the group without MS (3.4 days per month vs. 1.6 days per month). Why Does this Matter? This small, rigorous study adds important information on the commonness of headache in people with MS. Further study will help to determine why this would be, and lend insight into how best to manage headache in people with MS.Learn more… Meanwhile, people with MS and healthcare providers can learn strategies for catching the warning signs for headaches and how to manage them. Learn more about headache and other less common MS symptoms . Watch an “Ask the Expert” webinar on headaches to get strategies for preventing and treating headaches. Learn more about living with migraine and other headache disorders in videos from the National Headache Foundation. “Migraine and tension-type headache in multiple sclerosis: A two-year, prospective, longitudinal, controlled study” by Panagiotis Gklinos, Maria-Eleftheria Evangelopoulos, Georgios Velonakis, and Dimos-Dimitrios Mitsikostas is published in Multiple Sclerosis and Related Disorders 103 (2025) 106664.Investigators in Greece report that 96 people with MS were more than twice as likely to be diagnosed with any type of headache, and with migraine specifically, when compared with 96 people without MS. People with MS had higher levels of pain intensity and more frequent episodes of headache, compared with people without MS. Get strategies for preventing and treating headaches below. Background: Research shows that headache can appear as a symptom of MS. Most studies have been retrospective, a format that requires people to recall headache frequency and severity after the fact. A “prospective” study, which follows participants as the events are occurring, may produce more accurate findings.The Study: A team from National and Kapodistrian University of Athens tracked 96 people with MS and 96 controls without MS for two years. Participants filled out structured headache diaries that captured many aspects of headaches, including episode frequency and duration; pain location, quality and intensity; and monthly use of pain relievers.Results: Using powerful statistical methods to analyze the diaries, the team showed that people with MS were more than twice as likely to be diagnosed with any type of headache. Those with MS were more than twice as likely to be diagnosed with migraine headaches specifically.People with MS reported longer attack duration, higher pain intensity and increased frequency of episodes, compared with people without MS. The group with MS used pain relievers more frequently than the group without MS (3.4 days per month vs. 1.6 days per month). Why Does this Matter? This small, rigorous study adds important information on the commonness of headache in people with MS. Further study will help to determine why this would be, and lend insight into how best to manage headache in people with MS.Learn more… Meanwhile, people with MS and healthcare providers can learn strategies for catching the warning signs for headaches and how to manage them. Learn more about headache and other less common MS symptoms . Watch an “Ask the Expert” webinar on headaches to get strategies for preventing and treating headaches. Learn more about living with migraine and other headache disorders in videos from the National Headache Foundation. “Migraine and tension-type headache in multiple sclerosis: A two-year, prospective, longitudinal, controlled study” by Panagiotis Gklinos, Maria-Eleftheria Evangelopoulos, Georgios Velonakis, and Dimos-Dimitrios Mitsikostas is published in Multiple Sclerosis and Related Disorders 103 (2025) 106664.About Multiple Sclerosis Multiple sclerosis is an unpredictable disease of the central nervous system. Currently there is no cure. Symptoms vary from person to person and may include disabling fatigue, mobility challenges, cognitive changes, and vision issues. An estimated 1 million people live with MS in the United States. Early diagnosis and treatment are critical to minimize disability. Significant progress is being made to achieve a world free of MS. About the National Multiple Sclerosis Society The National MS Society, founded in 1946, is the global leader of a growing movement dedicated to creating a world free of MS. The Society funds cutting-edge research for a cure, drives change through advocacy and provides programs and services to help people affected by MS live their best lives. Connect to learn more and get involved: nationalmssociety.org , Facebook , X (formerly known as Twitter), Instagram , YouTube or 1-800-344-4867 . About Multiple Sclerosis Multiple sclerosis is an unpredictable disease of the central nervous system. Currently there is no cure. Symptoms vary from person to person and may include disabling fatigue, mobility challenges, cognitive changes, and vision issues. An estimated 1 million people live with MS in the United States. Early diagnosis and treatment are critical to minimize disability. Significant progress is being made to achieve a world free of MS. About the National Multiple Sclerosis Society The National MS Society, founded in 1946, is the global leader of a growing movement dedicated to creating a world free of MS. The Society funds cutting-edge research for a cure, drives change through advocacy and provides programs and services to help people affected by MS live their best lives. Connect to learn more and get involved: nationalmssociety.org , Facebook , X (formerly known as Twitter), Instagram , YouTube or 1-800-344-4867 .
Headache Study